PROBLEM TO BE SOLVED: To provide a biologically active granulated substance having good granulating properties and being release-controlled over a long period of time by suppressing the release rate of a biologically active substance when sprayed in a seedling box, a paddy field and a farmland.SOLUTION: A production method of a biologically active granulated substance is characterized in that a mixture containing (A) a biologically active substance, (B) an organic polyisocyanate and (C) an isocyanate reactive compound as essential components is granulated with an extrusion granulator and the granulated substance is heat-treated at a temperature of 40 to 120°C.COPYRIGHT: (C)2015,JPO&INPIT【課題】 造粒性が良好であり、育苗箱、水田及び畑地に散布した時、生物活性物質の放出速度を抑制し、長期間にわたって放出制御される生物活性粒状物を提供すること。【解決手段】 (A)生物活性物質、(B)有機ポリイソシアネート及び(C)イソシアネート反応性化合物を必須成分として含有する混合物を押出造粒機で造粒し、造粒物を40~120℃の温度で熱処理することを特徴とする生物活性粒状物の製造方法。【選択図】 なし