Method for producing oxalate oxidases having optical activity near physiological pH and use of such recombinant oxalate oxidases in the treatment of oxalate-related diseases
Recombinant oxalate oxidase having a sequence identity of at least 60% with the polypeptides of SEQ ID NO: 2, SEQ ID NO: 4 or SEQ ID NO: 6, or a sequence identity of at least 99% with the polypeptide of SEQ ID NO: 8, and in which the recombinant oxalate oxidase can degrade oxalate with a relative activity of at least 20% at pH 7.5, in which the relative activity is calculated as (observed activity (pH 7 , 5) / max activity) * 100%.Oxalato oxidasa recombinante que tiene una identidad de secuencia de al menos el 60% con los polipéptidos de SEQ ID NO: 2, SEQ ID NO: 4 o SEQ ID NO: 6, o una identidad de secuencia de al menos el 99% con el polipéptido de SEQ ID NO: 8, y en la que la oxalato oxidasa recombinante puede degradar oxalato con una actividad relativa de al menos el 20% a pH 7,5, en la que se calcula la actividad relativa como (actividad observada (pH 7,5)/actividad máx.) * 100%.
