HDAC inhibitors

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专利权人:

John S. Kovach;Francis Johnson

发明人:

John S. Kovach,Francis Johnson

申请号：

US12286769

公开号：

US08143445B2

申请日:

2008.10.01

申请国别(地区):

US

年份:

2012

代理人:

摘要：

This invention provides the compound having the structurewhereinn is 1-10；X is C—R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO—R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl；Z isR2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl；R5 is OH or SH； andR6, R12, R13, and R14 are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO—R15 wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, ora salt of the compound,which is useful in the treatment of tumors.

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