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HDAC inhibitors
专利权人:
John S. Kovach;Francis Johnson
发明人:
John S. Kovach,Francis Johnson
申请号:
US12286769
公开号:
US08143445B2
申请日:
2008.10.01
申请国别(地区):
US
年份:
2012
代理人:
摘要:
This invention provides the compound having the structurewhereinn is 1-10;X is C—R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO—R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl;Z isR2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl;R5 is OH or SH; andR6, R12, R13, and R14 are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO—R15 wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, ora salt of the compound,which is useful in the treatment of tumors.
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