Mario Varasi,Florian Thaler,Raffaella Amici,Agnese Abate,Maria Carmela Fulco,Saverio Minucci,Ciro Mercurio
申请号：
US13446861
公开号：
US08980877B2
申请日:
2012.04.13
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I), wherein: m and n are independently zero or an integer from 1 to 4； p is zero or an integer from 1 to 3, with the proviso that when p is zero, n and m cannot be both 1； R is hydrogen； C1-C6 alkyl, optionally substituted by C3-C8 cycloalkyl, C6-C10 aryl or hetero(C2-C9)aryl； (CO)R2； (SO2)R3； C3-C8 cycloalkyl； C6-C10 aryl； or hetero(C2-C9)aryl； R1 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy； Y is CH2 or NR4； Z is C═R5； and R2, R3, R4, and R5 are as further defined in the specification； and pharmaceutical acceptable salts thereof.
