Sathy V. Balu-Iyer,Robert Straubinger,Karthik Ramani,Razvan D. Miclea
申请号：
US12181178
公开号：
US08110218B2
申请日:
2008.07.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
