Raphael J. Mannino,Susan Gould-Fogerite,Sara L. Krause-Elsmore,David Delmarre,Ruying Lu
申请号：
US11653434
公开号：
US08642073B2
申请日:
2007.01.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
