#$%^&*AU2014262282A120141211.pdf#####ABSTRACT Antigen binding proteins with TCR-like paratopes, that is, with an antigen binding region specific for an HLA-A2 restricted peptide are disclosed. The antigen binding proteins encompass antibodies in a variety of forms, including 5 full-length antibodies, substantially intact antibodies, Fab fragments, F(ab)2 fragments, and single chain Fv fragments. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the specificity of the antigen binding region for each peptide are also contemplated by the invention. Furthermore, immunoconjugates may include 10 antibodies to which is linked a radioisotope, fluorescent or other detectable marker, cytotoxin, or other molecule are also encompassed by the invention. Among other things, immunoconjugates can be used for delivery of an agent to elicit a therapeutic effect or to facilitate an immune effector function. 5956397_1 (GHMatters) P94551.AU.1 WENDYB2/28 A 0.0.s 0J HlIt:A-A2-RFfPNAPYL 0.7 -R sq.:~Ht.A-A2.-SL GEQQYSV S0.6 HL ~ KA-A2-CMTiWNQMNL SVH&AA2-VISNDVCAQV 50- HL KA-A2-FLTPKKLQCV 0.4 2 HLA-A2-RLTRF SRV G HLA--A2-Et MLGEFLK.L a None 0.2 Clone 42 Clone 43 Clone 45 I g GHLA-A2-RMFPNAPYL 1.!*.-u~~. m HLA-A2-CMT WNQMNL 1 HLA-A%2-TLPPAWQPFL 1. 4HLA-A2-ALLMAGLAL ~ 1 2 ~- / ~ILA-A2-FLT.PKKQCV HLA-A2-V1SNDVCAQV H LA-A2-ALFDIESKV 6 HLA--A2--VILKKATEYV 0.6 N:HL A-A2-LMLGEFLKL R MIPNAPYL Peptide 0.2 f None 0 WT1 Clone 45 Anti-HLA-A2 Figure 2
