The invention discloses a kind of nasal composition of improved stability, purposes, technique production. Nose composition includes: xylometazoline hydrochloride (1), and 0.01-0.1% w/w Ipratropium bromide (2), 0.01-0.1% w/w Required final dosage form, which is formed, with pharmaceutical excipient is selected from the group being made up of: nasal drop, liquid, nose spray or nasal wass. The nasal composition includes the purifying sea water of content as function, and stability improvement excipient, dosage is 5-25% weight %. A kind of nasal composition has osmotic pressure within the scope of 270-820 mOsm/kg, and pH value is in the range of 3-7, preferably 3-4.2 or 5.8-7.In the range of 0, most preferably 3.2-4.Improved stability is shown at 2.
