광주과학기술원;GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
PARK, Woo Jin,박우진,JANG, Seung Pil,장승필
申请号：
KRKR2017/011796
公开号：
WO2018/080146A2
申请日:
2017.10.24
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a composition comprising a protein phosphatase 1 inhibitory peptide for treating vascular diseases. The composition of the present invention inhibits protein phosphatase 1 (PP1)-mediated dephosphorylation to suppress abnormal proliferation of vascular smooth muscle cells (VSMCs), and activates eNOS of vascular endothelial cells (VECs) to induce the recovery from dysfunction, and thus can be favorably used in the treatment of vascular diseases including pulmonary hypertension.La présente invention concerne une composition comprenant un peptide inhibiteur de protéine phosphatase 1 pour le traitement des maladies vasculaires. La composition selon la présente invention inhibe la déphosphorylation médiée par la protéine phosphatase 1 (PP1) pour supprimer une prolifération anormale des cellules musculaires lisses vasculaires (VSMC), et active la eNOS des cellules endothéliales vasculaires (VEC) pour induire la récupération de la dysfonction, et peut ainsi être favorablement utilisée dans le traitement des maladies vasculaires comprenant l'hypertension pulmonaire.본 발명은 단백질 탈 인산화 효소 1 억제 펩타이드(protein phosphatase 1 inhibitory peptides)를 포함하는 혈관 질환(vascular diseases) 치료용 조성물에 관한 것이다. 본 발명의 조성물은 PP1 (protein phosphatase 1)-매개 탈 인산화를 억제하여 혈관 평활근세포(vascular smooth nuscle cell, VSMCs)의 비이상적인 증식을 억제할 뿐만 아니라 혈관 내피세포 (vascular endothelial cells, VECs)의 eNOS를 활성화 시킴으로써 기능이상으로부터 회복을 유도하여 폐동맥 고혈압을 포함한 혈관질환의 치료에 유용하게 사용될 수 있다.
