調節ＨＳＰ９０活性的三唑化合物农业专利-农业学术服务平台

发明人:: YING, WEIWEN,英伟文,英偉文,JAMES, DAVID,大卫　詹姆士,大衛　詹姆士,ZHANG, SHIJIE,章世杰,PRZEWLOKA, TERESA,泰瑞莎　普雷罗卡,泰瑞莎　普雷羅卡,KOSTIK, ELENA,伊雷娜　寇斯堤克,CHAE, JUNGHYUN,徐永云,徐永雲,NG, HOWARD P.,霍华Ｐ　ＮＧ,霍華Ｐ　ＮＧ,DU, ZHENJIA,大卫詹姆士,大衛詹姆士,泰瑞莎普雷罗卡,泰瑞莎普雷羅卡,伊雷娜寇斯堤克,霍华P NG,霍華P NG

摘要：: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.本發明係關於經取代的三唑化合物與包含經取代的三唑化合物之組成物。本發明進一步係關於在一個需要抑制Hsp90活性的受藥者中抑制Hsp90活性之方法，與用於在一個需要預防或治療過度增殖失調症(例如癌症)的受藥者中預防或治療過度增殖失調症的方法，其包含將本發明之經取代的三唑化合物(或包含如此化合物之組成物)投藥至該受藥者。