TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY农业专利-农业专业知识服务系统

发明人:: YING, WEIWEN,英伟文,英偉文,SUN, LIJUN,孙利军,孫利軍,KOYA, KEIZO,古屋圭三,古屋圭三,CHIMMANAMADA, DINESH U.,迪尼许U 屈马纳马达,迪尼許U 屈馬納馬達,ZHANG, SHIJIE,章世杰,章世杰,PRZEWLOKA, TERESA,泰瑞沙普雷兹罗加,泰瑞沙普雷茲羅加,LI, HAO,李浩,李浩

摘要：: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.本發明係關於經取代的三唑化合物與包括經取代的三唑化合物之組成物。本發明進一步係關於在有需要的個體中抑制Hsp90之活性的方法以及供在有需要的個體中預防或治療過渡增生性失調(例如癌症)之用的方法,其包括投藥至該個體本發明的經取代的三唑化合物、或包括如此化合物的組成物。