The present invention relates to substituted triazole compounds andcompositions comprising substituted triazolecompounds. The invention further relates to methods of inhibiting the activityof Hsp90 in a subject in need thereof and methodsfor preventing or treating hyperproliferative disorders, such as cancer, in asubject in need thereof comprising administering to thesubject a substituted triazole compound of the invention, or a compositioncomprising such a compound.