EGAN, JAMES E.,OJIMA, IWAO,AMIJI, MANSOOR M.,BOTCHKINA, GALINA IVANOVNA
申请号：
CA3026412
公开号：
CA3026412A1
申请日:
2017.06.07
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multi-drug resistance by exposing a multi-drug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multi-drug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
