COMPOSITIONS DE NANOÉMULSION DE MÉDICAMENTS TAXOÏDES, ET LEURS PROCÉDÉS D'UTILISATION POUR CIBLER DES CELLULES CANCÉREUSES ET DES CELLULES SOUCHES CANCÉREUSES
Targagenix, Inc.;The Research Foundation of the State University of New York;Northeastern University
发明人:
EGAN, James E.,OJIMA, Iwao,AMIJI, Mansoor M.,BOTCHKINA, Galina Ivanovna
申请号：
EP17810927
公开号：
EP3463299A4
申请日:
2017.06.07
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
