Yu Lei,Yee Sun Tan,Kanokwan Sansanaphongpricha,Duxin Sun,Hongwei Chen,Hongxiang Hu
申请号：
US16619802
公开号：
US20200129640A1
申请日:
2018.06.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides methods, compositions, systems, and kits comprising nano-satellite complexes and/or serum albumin carrier complexes, which are used for modulating antigen-specific immune response (e.g., enhancing anti-tumor immunity). In certain embodiments, the nano-satellite complexes comprise: a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core； b) at least one satellite particle attached to, or absorbed to, the biocompatible coating； and c) an antigenic component conjugated to, or absorbed to, the at least one satellite particle component. In certain embodiments, the complexes further comprise: d) an type I interferon agonist agent. In some embodiments, the serum albumin complexes comprise: a) at least part of a serum albumin protein, b) an antigenic component conjugated to the carrier protein, and c) a type I interferon agonist agent.
