INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YONSEI UNIVERSITY
发明人:
YU JE WOOK,YANG JUNG MIN
申请号：
KR20180064608
公开号：
KR20180066000A
申请日:
2018.06.05
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a composition for alleviating, preventing or treating an inflammasome mediated inflammatory disease. When using N-acyl homoserine lactone (AHL) based compounds, formation of an adaptive protein apoptosis-associated spec-like protein containing a caspase-recruitment domain (ASC) polymer can be inhibited to reduce activation of NLRP3 inflammasome, thereby exhibiting effect on alleviating, preventing or treating the disease.본 발명은 인플라마좀 매개 염증성 질환의 개선, 예방 또는 치료용 조성물에 관한 것으로, N-아실 호모세린 락톤(N-acyl homoserine lactone AHL) 계열의 화합물을 사용하는 경우 체내 ASC(adaptor protein apoptosis-associated spec-like protein containing a caspase-recruitment domain) 중합체 형성의 억제를 통하여, NLRP3 인플라마좀 활성화를 감소시켜 상기 질환의 개선, 예방 또는 치료에 효과를 발휘할 수 있다.
