ONCOLYTIC ADENOVIRUS COMPOSITIONS

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专利权人:

Salk Institute for Biological Studies

发明人:

OSHEA, Clodagh,MIYAKE-STONER, Shigeki

申请号：

EP14770520

公开号：

EP2971008B1

申请日:

2014.03.14

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

An adenovirus comprising an E1A polypeptide comprising one or more modifications and comprising an E4orf6/7 polypeptide comprising one or more modifications is described. Compositions and kits comprising the modified adenoviruses are also described. Further described is a method of treating a proliferative disorder in a subject comprising administering to the subject an adenovirus comprising the E1A polypeptide comprising one or more modifications and comprising the E4orf6/7 polypeptide comprising one or more modifications.

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