SALK INST FOR BIOLOGICAL STUDI;Salk Institute for Biological Studies
发明人:
申请号:
EP14770520.6
公开号:
EP2971008B1
申请日:
2014.03.14
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
An adenovirus comprising an E1A polypeptide comprising one or more modifications and comprising an E4orf6/7 polypeptide comprising one or more modifications is described. Compositions and kits comprising the modified adenoviruses are also described. Further described is a method of treating a proliferative disorder in a subject comprising administering to the subject an adenovirus comprising the E1A polypeptide comprising one or more modifications and comprising the E4orf6/7 polypeptide comprising one or more modifications.