CHAMPION, BRIAN ROBERT,BROMLEY, ALICE CLAIRE NOEL,FREEDMAN, JOSHUA DAVID,FISHER, KERRY DAVID,SEYMOUR, LEONARD WILLIAM
申请号：
CA3033267
公开号：
CA3033267A1
申请日:
2017.08.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engager (BiTE) each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
