Brian Robert CHAMPION,Alice Claire Noel BROMLEY,Joshua David FREEDMAN,Kerry David FISHER,Leonard William SEYMOUR
申请号：
US16329125
公开号：
US20190233536A1
申请日:
2017.08.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engager (BiTE™；) each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
