Werner J. Geldenhuys;Michael A. Menze;Mary E. Konkle
发明人:
Mary E. Konkle,Michael A. Menze,Werner J. Geldenhuys
申请号：
US16448312
公开号：
US20190388381A1
申请日:
2019.06.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods of inhibiting formation of complexes of CDGSH iron-sulfur domain (CISD) protein and pyridoxal-5′；-phosphate (PLP) are provided herein. More specifically, methods of inhibiting formation of CISD protein-PLP complexes include exposing a CISD protein to a compound with specific binding affinity for a designated lysine residue in the CISD protein. Inhibition of CISD protein-PLP complex formation is relevant to disease states associated with the CISD protein-PLP complex.
