Vincent Craig Bond,Michael Powell,Ming Bo Huang,Syed Ali,Martin N. Shelton
申请号：
US16811754
公开号：
US20200197483A1
申请日:
2020.03.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
