Jaehoon Yu,Yan Lee,Soonsil Hyun,Seo Yeon Kim,Sun Mi Jin,Yunhwa Choi,Doyeon Jo,Seonju Lee
申请号：
US15761089
公开号：
US20180339016A1
申请日:
2016.09.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
