Novel 1,2,3,4-tetrahydroquinoxaline derivative having a glucocorticoid receptor binding activity and having a phenyl group having a sulfonic acid ester or sulfonic acid amide structure introduced as a substituent
The compounds represented in general formula (1) or a salt thereof are useful for glucocorticoid receptor modulators. In the formula, R 1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group and the like； R 2 represents a hydrogen atom, a lower alkyl group and the like； R 3 represents a hydrogen atom, a lower alkyl group and the like； R 4 and R 5 represent a hydrogen atom, a lower alkyl group and the like； R 6 represents a hydrogen atom, a lower alkyl group and the like； R 7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group and the like； W represents an oxygen atom, a sulfur atom, NR 8 and the like； R 8 represents a hydrogen atom, a lower alkyl group and the like； X represents an oxygen atom or a sulfur atom； Y represents a lower alkylene group and the like； Z represents an oxygen atom, a sulfur atom, NR 9 , OCO or OSO 2 ； R 9 represents a hydrogen atom, a lower alkyl group and the like respectively.
