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Derivatives of substituted amides of amino acids with urea as n - formyl peptide receptor modulators Receptor Type 1 (fprl - 1)
- 专利权人:
- INC.;ALLERGAN
- 发明人:
- 申请号：
- ARP120104004
- 公开号：
- AR088535A1
- 申请日:
- 2012.10.25
- 申请国别(地区):
- AR
- 年份:
- 2014
- 代理人:
- 摘要：
- Claim 1: compound (1) represented by formula,its enantiomers, diastereoisomers, tautomers, hydrates, solvates or a pharmaceutically acceptable salt thereof, wherein: a is 1 and b is 0； a is 0 and b is 1； a is 1 and b is 1； R¹ is optionally substituted C₁₋₈ alkyl, optionally substituted C₃₋₈ cycloalkyl, optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl, optionally substituted C₃₋₈ cycloalkenyl, -NR¹¹R¹² or -OR¹³；R² is optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl； R³ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322；optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl； R⁴ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322；optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl； R⁵ is halogen, -CF₃ or -S (O) ₙR¹⁴；n is 0, 1 or 2； R⁶ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322；optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl； R⁷ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322；optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl； R⁸ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl； R⁹ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl； R¹⁰ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl； R⁹ᵃ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl； R¹⁰ᵃ is hydrogen,optionally substituted C₁₋₈ a
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
