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Derivatives of substituted amides of amino acids with urea as n - formyl peptide receptor modulators Receptor Type 1 (fprl - 1)
- 专利权人:
- INC.;ALLERGAN
- 发明人:
- 申请号:
- ARP120104004
- 公开号:
- AR088535A1
- 申请日:
- 2012.10.25
- 申请国别(地区):
- AR
- 年份:
- 2014
- 代理人:
- 摘要:
- Claim 1: compound (1) represented by formula,its enantiomers, diastereoisomers, tautomers, hydrates, solvates or a pharmaceutically acceptable salt thereof, wherein: a is 1 and b is 0; a is 0 and b is 1; a is 1 and b is 1; R¹ is optionally substituted C₁₋₈ alkyl, optionally substituted C₃₋₈ cycloalkyl, optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl, optionally substituted C₃₋₈ cycloalkenyl, -NR¹¹R¹² or -OR¹³;R² is optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl; R³ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322;optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl; R⁴ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322;optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl; R⁵ is halogen, -CF₃ or -S (O) ₙR¹⁴;n is 0, 1 or 2; R⁶ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322;optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl; R⁷ is hydrogen, optionally substituted C₁₋₈ alkyl, halogen, -COOR¹⁵,- Oran 3,-1 numberNo.8322;optionally substituted heterocycle, optionally substituted C₃₋₈ cycloalkyl, optionally substituted C₆₋₁₀ aryl or optionally substituted C₃₋₈ cycloalkenyl; R⁸ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl; R⁹ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl; R¹⁰ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl; R⁹ᵃ is hydrogen, optionally substituted C₁₋₈ alkyl or optionally substituted C₆₋₁₀ aryl; R¹⁰ᵃ is hydrogen,optionally substituted C₁₋₈ a
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