THERESA M. BALLARD,SILVIA GATTI MARTHUR,THOMAS WOLTERING,JUERGEN WICHMANN,MICHAEL SAXE
申请号：
ARP150101202
公开号：
AR100151A1
申请日:
2015.04.22
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
They are mglu2 / 3 negative Western Sahara modulators for the treatment of various mental disorders. On the other hand, this document refers to the pharmaceutical ingredients used to treat various mental disabilities, including a currently agreed compound and a pharmaceutically acceptable means of transport. Claim 2: mglu2 / 3 negative Western Sahara stratospheric modulator selected from a compound according to the first requirement, the formula of which is (1) and (2), where E and j are n, G is C, 1 is l or m is n, 1 is n, 1 is l and G is n, e is C, J and m are ch；or J, G and L are N, E is C and M is CH； or E and L are N, J and M are CH and G is C； A is selected from the group including phenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyridazin-2-yl, pyridazin-3-yl , thiazol-2-yl, thiazol-5-yl, and thiophene-2-yl which are optionally substituted by one to four Rᵃ；B selected from methyl picolinate, [1.2.4] oxadiazolilo, pirrolilo, 1H pirazolilo, piridinil, [1.2.4] triazolo, tiazolo, pirimidinilo and tiofenil, each of which can be replaced by a c83833126 asphalt；C is arilo or 5 or 6 heterosexual members of optional substitution, and the substitutes are selected from a group of members including (12) halogen, 13) nitro, 14) c83218326. The substitutes are a hydrogen Xi, 15) nr7491；； r7495；； 74955；wherein Rᵃᵃ and Rᵇᵇ are independently H, a C₁₋₆ alkyl or a - (CO) -C₁₋₆ alkyl,xvi) a -S-C₁₋₆-alkyl,xvii) - (SO₂) -OH, xviii) a - (SO₂) -C₁₋₆ alkyl,xix) - (SO₂) -NRᶜᶜRᵈᵈ,wherein Rᶜᶜ and Rᵈᵈ are independently: j) H, k) a C₁₋₆ alkyl optionally substituted by a hydroxy, l) a C₁₋₆ haloalkyl,) Un alcoxi Cn) un - (CO) -alquilo C sustituido de forma opcional por un alcoxi Co) - (CH CH O) CHRwhere Rᵉᵉ is H or CH₂OH and n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, p) un - (CH₂) ₘ-aryl, where m is 1 or 2 and aryl is optionally substituted by a halo or a C₁₋₆ alkoxy,q) un - (CH) -cicloalquilo CHeterosexual (XX) - (so832222) - nr75484； - r7501；； 7501； P is 0 or 1,
