1,2,3,4-tetrahydroquinoxaline compound with a phenyl group substituent having a sulfonic acid ester structure or a sulfonic acid amide structure introduced therein and having glucocorticoid receptor-binding activity
The compounds represented in general formula (1) or a salt thereof are useful for glucocorticoid receptor modulators. In the formula, R1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group and the like； R2 represents a hydrogen atom, a lower alkyl group and the like； R3 represents a hydrogen atom, a lower alkyl group and the like； R4 and R5 represent a hydrogen atom, a lower alkyl group and the like； R6 represents a hydrogen atom, a lower alkyl group and the like； R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group and the like； W represents an oxygen atom, a sulfur atom, NR8 and the like； R8 represents a hydrogen atom, a lower alkyl group and the like； X represents an oxygen atom or a sulfur atom； Y represents a lower alkylene group and the like； Z represents an oxygen atom, a sulfur atom, NR9, OCO or OSO2； R9 represents a hydrogen atom, a lower alkyl group and the like respectively.
