GROMADA, Jesper,SMITH, Eric,MURPHY, Andrew,PAPADOPOULOS, Nicholas,MARTIN, Joel,YANCOPOULOS, George,MACDONALD, Douglas,BUCKLER, David
申请号：
EP15751746
公开号：
EP3107565A4
申请日:
2015.02.20
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention provides, inter alia, a method for cell-specific modulation of a target antigen. The method comprises contacting a target cell having the target antigen on the surface of the target cell with: (a) first multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C1), (ii) a target antigen binding domain (T1) and (b) a second multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C2), (ii) a target antigen binding domain (T2) wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. Pharmaceutical compositions and kits thereof are also included in the present invention.
