GROMADA, JESPER,SMITH, ERIC,MURPHY, ANDREW,PAPADOPOULOS, NICHOLAS,MARTIN, JOEL,YANCOPOULOS, GEORGE,MACDONALD, DOUGLAS,BUCKLER, DAVID
申请号：
HK17104976.1
公开号：
HK1231374A
申请日:
2017.05.17
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention provides, inter alia, a method for cell-specific modulation of a target antigen. The method comprises contacting a target cell having the target antigen on the surface of the target cell with: (a) first multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C1), (ii) a target antigen binding domain (T1) and (b) a second multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C2), (ii) a target antigen binding domain (T2) wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. Pharmaceutical compositions and kits thereof are also included in the present invention.
