Dennis Klinman,Daniela Verthelyi,Ken Ishii,James J. Mond,Mayda Gursel
申请号：
US13104918
公开号：
US08227446B2
申请日:
2011.05.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula:5′X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3′wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
