The United States of America as represented by the Secretary of the Department of Health and Human Services
发明人:
Dennis M. Klinman,Ken J. Ishii,Daniela Verthelyi,James J. Mond
申请号：
US13759922
公开号：
US08741869B2
申请日:
2013.02.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A substantially pure or isolated oligodeoxynucleotide of at least 10 nucleotides is disclosed, wherein the oligodeoxynucleotide comprised a sequence represented by either formula:5′ N1N2N3T-CpG-WN4N5N6 3′wherein the CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are nucleotides, or the formula:5′ RY-CpG-RY 3′wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host. In some embodiments, the oligodeoxynucleotide includes the nucleic acid sequences set forth as SEQ ID NO: 137.
