Pyrazole compounds and substituted pyrroles, modulators of the Orphan nuclear receptor ROR gamma； Pharmaceutical Composition and use in the Treatment or prophylaxis of Diseases of the immune system such as rheumatoid arthritis, lupus, multiple sclerosis, COPD, among others. Ace.
GEGE CHRISTIAN,KINZEL OLAF,STEENECK CHRISTOPH,KLEYMANN GERALD,HOFFMANN THOMAS
申请号：
CL2015000300
公开号：
CL2015000300A1
申请日:
2015.02.06
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The invention provides modulators for the orphan nuclear receptor ROR³ and methods for treating ROR³ mediated diseases by administering these novel ROR³ modulators to a human or a mammal in need thereof. Specifically, the present invention relates to compounds for use ROR³ modulators, wherein the compounds are carboxamide containing cyclic compounds of Formula ( 6 ) to Formula ( 9 ) and the enantiomers, diastereomers, tautomers, N-oxides, solvates and pharmaceutically acceptable salts thereof.<；p>；COMPUESTOS DERIVADOS DE 3-PIRROLOCARBOXAMIDA, 2-PIRROLOCARBOXAMIDA Y 3-PIRAZOLOCARBOXAMIDA SUSTITUIDOS, MODULADORES DEL RECEPTOR NUCLEAR HUERFANO ROR GAMMA； COMPOSICION FARMACEUTICA； Y USO PARA EL TRATAMIENTO O PROFILAXIS DE ENFERMEDADES INFLAMATORIAS Y AUTOINMUNES CRÓ；NICAS, TALES COMO ARTRITIS REUMATOIDE, PSORIASIS, ENTRE OTRAS<；/p>；
