Compounds quinoline derivatives as modulators of nuclear receptor ROR gammat； Pharmaceutical composition that comprises； its elaboration process, useful for the treatment of an inflammatory disease such as rheumatoid arthritis, psoriasis, Crohn's disease, COPD, multiple sclerosis Systemic lupus erythematosus, and ulcerative colitis.
LEONARD KRISTI A.,BARBAY KENT,EDWARDS JAMES P.,KREUTTER KEVIN D.,KUMMER DAVID A.,MAHAROOF UMAR,NISHIMURA RACHEL,URBANSKI MAUD,VENKATESAN HARIHARAN,WANG AIHUA,WOLIN RONALD L.,WOODS CRAIG R.,PIERCE JOAN
申请号：
CL2015000945
公开号：
CL2015000945A1
申请日:
2015.04.15
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&gamma；t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.<；p>；LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE QUINOLINA CON UN CONECTOR METILENICO, MODULADORES DEL RECEPTOR NUCLEAR ROR-GAMMA-T, A UNA COMPOSICIÓ；N FARMACÉ；UTICA QUE LOS COMPRENDE, A UN PROCESO DE ELABORACIÓ；N DE LA COMPOSICIÓ；N Y A SU USO DEL COMPUESTO O COMBINACIÓ；N DE ESTE EN ARTRITIS REUMATOIDE, PSORIASIS, ENFERMEDAD DE CROHN, ENTRE OTRAS<；/p>；
