BAYBURT, EROL K.,CLAPHAM, BRUCE,COX, PHIL B.,DAANEN, JEROME F.,GOMTSYAN, ARTHUR,KORT, MICHAEL E.,KYM, PHILIP R.,VOIGHT, ERIC A.
申请号：
PE0002312013
公开号：
PE10452013A1
申请日:
2010.08.10
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a compound of formula (i), where ra and RB are h, alkyl C1 - C10, haloalquilo C1 - C10, among others or is an integer from 0 to 2 X3 is CH2, o, S, among others x4 is a Union or (CH2) x5 m is a Union or (CH2) n M and N are integers from 1 to 4 Z1 is C1 - C10 alkyl (alkyl, or C1 - C10), Oxo, among ot Ros p is an integer from 0 to 4 x1 x2 is o h G1 is such as aryl phenyl or naphthyl,Heteroaryl monociclico of 5 or 6 members cycloalkyl C3, C8, among others G2 is G2D or - R - (cr1gr2g G2D) R is an integer from 1 to 3 and r1g r2g is H, or C1 - C10 alkyl (alkyl, C1 - C10), such as aryl G2D is phenyl or naphthyl heteroaryl monociclico, 5 or 6 members, among others.Preferred compounds are: [1 - (2-fluorophenyl) cyclobutyl] (pyridin-2-yl) methanol [1 - (3-fluorophenyl) cyclobutyl] (pyridin-2-yl) methanol [1 - (4-fluorophenyl) cyclobutyl (pyridin-2-yl) methanol, among others. It also relates to a Pharmaceutical composition.These compounds are modulators of Transient Receptor Potential vainilloide 3 (TRPV3) and are useful for treating conditions associated with chronic pain, neuropathic pain, nociceptive Pain, among othersREFERIDA A UN COMPUESTO DE FORMULA (I), DONDE Ra y Rb SON H, ALQUILO C1-C10, HALOALQUILO C1-C10, ENTRE OTROS U ES UN ENTERO DE 0 A 2 X3 ES CH2, O, S, ENTRE OTROS X4 ES UNA UNION O (CH2)m X5 ES UNA UNION O (CH2)n m Y n SON ENTEROS DE 1 A 4 Z1 ES ALQUILO C1-C10, O(ALQUILO C1-C10), OXO, ENTRE OTROS p ES UN ENTERO DE 0 A 4 X1 ES OH X2 ES H G1 ES ARILO TAL COMO FENILO O NAFTILO, HETEROARILO MONOCICLICO DE 5 O 6 MIEMBROS, CICLOALQUILO C3-C8, ENTRE OTROS G2 ES G2d O -(CR1gR2g)r-G2d r ES UN ENTERO DE 1 A 3 R1g Y R2g SON H, ALQUILO C1-C10, O(ALQUILO C1-C10), G2d ES ARILO TAL COMO FENILO O NAFTILO, HETEROARILO MONOCICLICO DE 5 O 6 MIEMBROS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [1-(2-FLUOROFENIL)CICLOBUTIL](PIRIDIN-2-IL)METANOL, [1-(3-FLUOROFENIL)CICLOBUTIL](PIRIDIN-2-IL)METANOL, [1-(4-FLUOROFENIL) CICLOBUTIL(PIRIDIN-2-IL)METANOL, ENTRE OTROS. TAMBIEN ESTA RE
