CLAFFEY, MICHELLE MARIE,DOUNAY, AMY BETH,GAN, XINMIN,HAYWARD, MATHEW MERRILL,RONG, SUOBAO,TUTTLE, JAMISON BRYCE,VERHOEST, PATRICK ROBERT
申请号：
PE0021062011
公开号：
PE04322012A1
申请日:
2010.05.26
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a Heterocyclic Compound of formula (X), where X is n or CR1, CR2 is n or N and Z is n or or Cr3, CR4, R1 is H, alkyl C1 - C10 alkoxy, C1 - C10, ciclopropilo R2, R3 and R4 are h, halogen, alkyl of C1 - C10 alkoxy, C1 - C10 is H, among others R5, R9 C (= o), C (= o) or9, among others and r6a R6B are H F, Methyl, halometilo, among others R9 is C1 - C10 alkyl, aryl ciclalquilo C6 C10 c6-c18,Among others. Preferred compounds are: 3 - amino - 7-chloro-1 - hydroxy - 3.4 - dihidroquinolin - 2 (1H) - One, 2 - amino - 1 - hydroxy - 7 - methyl - 4 - dihidroquinolin - 2 (1H) - One, 3 - amino - 4 - chlorine - 1 - hydroxy - 8 - dihidroquinolin - 3,4 - (trifluoromethyl) - 2 (1H) - One, among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of the Enzyme kynurenine aminotransferase II (KAT II) and are useful in the treatment of Cognitive deficits associated with schizophrenia and other Neurological and \/ or neurodegenerative DisordersREFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (X), DONDE A ES N O CR1 X ES N O CR2 Y ES N O CR3 Z ES N O CR4 R1 ES H, ALQUILO C1-C10, ALCOXI C1-C10, CICLOPROPILO R2, R3 Y R4 SON H, HALOGENO, ALQUILO C1-C10, ALCOXI C1-C10, ENTRE OTROS R5 ES H, C(=O)R9, C(=O)OR9, ENTRE OTROS R6a Y R6b SON H, METILO, F, HALOMETILO, ENTRE OTROS R9 ES ALQUILO C1-C10, CICLALQUILO C6-C10, ARILO C6-C18, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-AMINO-7-CLORO-1-HIDROXI-3,4-DIHIDROQUINOLIN-2(1H)-ONA, 3-AMINO-1-HIDROXI-7-METIL-3,4-DIHIDROQUINOLIN-2(1H)-ONA, 3-AMINO-6-CLORO-1-HIDROXI-8-(TRIFLUOROMETIL)-3,4-DIHIDROQUINOLIN-2(1H)-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA QUINURENINA AMINOTRANSFERASA II (KAT II) Y SON UTILES EN EL TRATAMIENTO DE DEFICITS COGNITIVOS ASOCIADOS A LA ESQUIZOFRENIA Y OTROS TRASTORNOS NEURODEGENERATIVOS Y/O NEUROLOGICOS
