The present invention provides a combination of a compound represented by general formula (1) or the salt thereof and a statin drug, especially pitavastatin, for using as a preventive and/or therapeutical agent of hyperlipemia, obesity or diabetes, and metabolic syndrome:Wherein, R1and R2are identical or different and represent hydrogen, methyl, or ethyl R3a, R3b, R4a and R4b are identical or different and represent hydrogen, halogen, nitro, hydroxyl, C1-4alkyl, trifluoromethyl, C1-4alkyloxy, C1-4alkylcabonyloxy, di-C1-4alkylamino, C1-4alkylsulfonyloxy, C1-4alkylsulfonyl, C1-4alkylsulfinyl, or C1-4alkylthio group R3a and R3b or R4a and R4b together represent alkylenedioxy X represents oxygen, sulfur, or N-R5(R5represents hydrogen, C1-4alkyl, C1-4alkylsulfonyl, C1-4alkyloxycarbonyl) Y represents oxygen, S (O)1group (1 represents a number of 0 ~ 2) , carbonyl, carbonylamino, aminocarbonyl, sulfonylamino, aminosulfonyl, or NH group Z represents CH or N n represents a number of 1~6 m represents a number of 2~6.本發明提供一種具有優異地降低血漿中之膽固醇濃度及甘油三酯濃度之效果之高脂血症治療劑。本發明係關於一種將以下通式(1)表示之化合物或其鹽與他汀類,特別係匹伐他汀類組合之高脂血症之預防及/或治療劑、肥胖或糖尿病之預防及/或治療劑、以及代謝綜合症之預防及/或治療劑(式中,R1及R2係相同或不同地表示氫原子、甲基或乙基;R3a、R3b、R4a及R4b係相同或不同地表示氫原子、鹵素原子、硝基、羥基、C1-4烷基、三氟甲基、C1-4烷氧基、C1-4烷基羰基氧基、二-C1-4烷基胺基、C1-4烷基磺醯氧基、C1-4烷基磺醯基、C1-4烷基亞磺醯基、或C1-4烷硫基;R3a與R3b或者R4a與R4b結合表示亞烷基二氧基;X表示氧原子、硫原子或N-R5(R5表示氫原子、C1-4烷基、C1-4烷基磺醯基、C1-4烷氧基羰基);Y表示氧原子、S(O)1基(1表示0~2之數)、羰基、羰基胺基、胺羰基、磺醯基胺基、胺基磺醯基、或NH基;Z表示CH或N;n表示1~6之數;m表示2~6之數)。
