Vivekanandan Sundaramoorthy,Anandsenthilvel Palanisamy,Sampathkumar Devarajan,Jeffrey Stuart Bergman
申请号：
US13881186
公开号：
US20130217774A1
申请日:
2011.10.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Preparing a dexibuprofen pharmaceutical formulation in the form of granules that can be directly compressed into tablets. The process consists of two steps: (i) preparation of base granules, and (ii) blending base granules with a compression aid. The process of preparing base granules involves use of liquid bed granulator with top spray method, or slugging by roll compaction. The granules prepared by using both the methods showed improved compressibility and flowability compared to granules prepared by conventional granulation process using rapid mixer granulator. The ready-to-compress granules prepared by the process show no signs of sticking when compressed on a high-speed commercial scale tablet compression machine.
