Sumitomo Dainippon Pharma Co., Ltd.;AstraZeneca AB
发明人:
KURIMOTO, Ayumu,HASHIMOTO, Kazuki,ISOBE, Yoshiaki,BROUGH, Stephen,MILLICHIP, Ian,WADA, Hiroki,BONNERT, Roger,MCINALLY, Thomas
申请号：
ES05727100
公开号：
ES2563952T3
申请日:
2005.03.24
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
An 8-oxoadenine compound shown by formula (1): ** Formula ** wherein ring A represents a 6-10 membered aromatic carbocyclic ring, or a 5-10 membered heteroaromatic ring containing 1-4 heteroatoms selected from 0-4 nitrogen atoms, 0-2 oxygen atoms and 0-2 sulfur atoms； R represents a halogen atom, a 1-6 carbon alkyl group, a 1-6 carbon hydroxyalkyl group, a 1-6 carbon haloalkyl group, a 1-6 carbon alkoxy group, a 1-6 hydroxyalkoxy group carbons, a haloalkoxy group of 1-6 carbons, an amino group, an alkylamino group of 1-6 carbons, a dialkylamino group in which each alkyl radical has 1-6 carbons, or a cyclic amino group； n is an integer from 0 to 2, and when n is 2, the R may be the same or different； Z1 represents an alkylene group of 1-6 carbons or a cycloalkylene group of 3-8 carbons, which is optionally substituted with a hydroxy group； X2 represents an oxygen atom, a sulfur atom, SO2, NR5, NR5SO2 or NR5CONR6 (in which R5 and R6 are independently a hydrogen atom, a substituted or unsubstituted alkyl group of 1-6 carbons or a substituted cycloalkyl group or unsubstituted of 3-8 carbons, wherein the substituents of the alkyl group, or of the cycloalkyl group are selected from a halogen atom, a hydroxy group, an alkoxy group of 1-6 carbons, a carboxyl group, an alkoxycarbonyl group of 2-5 carbons, a carbamoyl group, an amino group, an alkylamino group of 1-6 carbons, a dialkylamino group in which each alkyl radical has 1-6 carbons, a cyclic amino group, and a tetrazolyl group that can be substituted with an alkyl group of 1-6 carbons)； Y1, Y2 and Y3 independently represent a single bond or an alkylene group of 1-6 carbons； X1 represents an oxygen atom, a sulfur atom, SO2, NR4 (where R4 represents a hydrogen atom or an alkyl group), or a single bond； R 2 represents a substituted or unsubstituted alkyl group of 1-6 carbons, a substituted or unsubstituted alkenyl group of 2-6 carbons having 1-3 double bonds, a substituted or unsubstituted alkynyl group of 2-6 carbons ha
