DERIVATIVE OF DIAMINOPIRIMIDINCARBOXAMIDA.

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专利权人:

ASTELLAS PHARMA INC.

发明人:

NAGASHIMA, S.,NAGATA, H.,IWATA, M.,YOKOTA, M.,MORITOMO, H.,NAKAI, E.,KUROMITSU, S.,OHGA, K.,TAKEUCHI, M.

申请号：

ES03761820

公开号：

ES2373226T3

申请日:

2003.06.26

申请国别(地区):

ES

年份:

2012

代理人:

摘要：

A compound represented by the formula (I) or a salt thereof wherein A 1: CR 5 or N, R 5: -H, C1-C6 alkyl, -O-C1-C6 alkyl or -halogen, A 2: CR 6 or N, R 6: -H or -halogen, R 3: -R 0, -C1-C6 alkyl substituted by halogen, -halogen, -OR 0, -S-C1-C6 alkyl, -CO-C1-C6 alkyl , -CO2-C1- C6 alkyl, -C1-C6 alkyl -OH, -hetero ring, -O-hetero ring, -N (R 0) -hetero ring, alkylene (C1-C6) -hetero ring, -Okylene (C1- C6) -hetero-ring, -S-alkylene (C1-C6) -hetero-ring, -SO-alkylene (C1-C6) -hetero-ring, -SO2-alkylene (C1-C6) hetero-ring, -N (R 0) -alkylene (C1 -C6) -hetero-ring, -alkylene (C1-C6) -CO-hetero-ring, alkylene (C1-C6) -N (R 0) 2, -SO2-N (R 0) -C1-C6 alkyl or -C1-alkyl -C6) -N (R 0) -CO2-alkylene (C1-C6) -phenyl, R 0: same or different from each other, and each is H or C1-C6 alkyl, n: 0 or 2, R 4: (i) when n = 2, -R 0, -C1-C6 alkyl substituted by halogen, -OR 0, -N (R 0) -CHO, -N (R 0) -CO-C1-C6 alkyl or -N (R 0) -SO2-C1-C6 alkyl, SO2-C1-C6 alkyl, (ii) when do n = 0, -H, -C1-C6 alkyl substituted by halogen, -OH, -NH-CHO, -CON (R 0) 2, -C1-C6 alkylene substituted by halogen-OH, -C1-C6 alkylene ) -NH2, -C1-C6 alkylene -NHCONH2, -C1-C6-alkylene -CO2H, -C1-C6-alkylene -CO2- -C1-C6-alkyl, -C1-C6-alkylene -CN, or -CH (-alkylene (C1-C6) -OH) 2, or a group represented by the formula -X to -R 4a, X a: single bond, -O-, -CO-, -S-, -SO2 -, -N (R 0) -, -N (R 0) CO-, -N (R 0) SO2-, -alkylene (C1-C6) -O-, -alkylene (C1-C6) - N (R 0) -, -alkylene (C1-C6) -N (R 0) CO-, -alkylene (C1-C6) -N (R 0) SO2-, -alkylene (C1-C6) -N (R 0) CO2 -, -N (CO-R 0) -, -N (SO2 C1-C6 alkyl) -, -CON (R 0) -, -alkylene (C1-C6) -O-CO-, -alkenylene (C1-C6) -CO-, -alkenylene (C1-C6) -CON (R 0) -, -alkenylene (C1-C6) -CO2-, -O- (CH2) k-cycloalkylene- (CH2) m-, -N (R 0) - (CH2) k-cycloalkylene- (CH2) m-, -CO- (CH2) kcycloalkylene- (CH2) m-, -CON (R 0) - (CH2) k-cycloalkylene- (CH2) m- or -N (R 0) CO- (CH2) k-cycloalkylene- (CH2) m-, kym, equal or different from each other, and each is 0, 1, 2, 3 or 4, R 4a: -C1 alk

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