您的位置: 首页 > 农业专利 > 详情页

DERIVATIVES OF ALKALOID AMINOESTER AND THEIR DRUG COMPOSITIONS
专利权人:
KEZI FARMACHEUTICHI S.P.A.;K'EZI FARMACHEUTICHI S.P.A.
发明人:
AMARI Gabriehle (IT),АМАРИ Габриэле (IT),RIKKABONI Mauro (IT),РИККАБОНИ Мауро (IT),AMARI GABRIEHLE,АМАРИ Габриэле,RIKKABONI MAURO,РИККАБОНИ Мауро
申请号:
RU2012155691/04
公开号:
RU0002567548C2
申请日:
2011.05.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compounds of general formulaand their pharmaceutically acceptable salts, which have action of antagonist of muscarine receptors. In formula (I) R1 is selected from group, which consists of (C1-C6)alkyl, (C3-C8)cycloalkyl, phenyl, benzyl and thiophenyl, optionally substituted with one or more substituents, selected from atoms of halogen, OH, oxo, SH, NH2, NO2, CN, CONHR5, CON(R5)2, NHCOR5, COR5, CO2R5, etc.; R2 represents H or (C1-C6)alkyl, optionally substituted with one or more substituents, selected from group, which consists of atoms of halogen, OH, oxo, SH, NH2, NO2, CN, CONHR5, CON(R5)2, NHCOR5, COR5, CO2R5, etc.; R3 represents H or is selected from group, which consists of (C1-C6)alkyl, (C3-C8)cycloalkyl, phenyl, thiophenyl, benzothiophenyl and pyridyi, optionally substituted with one or more substituents, selected from group, which consists of atoms of halogen, OH, oxo, SH, NH2, NO2, CN, CONHR5, CON(R5)2, CO2R5, etc.; R6 represents group of formula , where A stands for physiologically acceptable anion; R4 represents group of formula , where p is equal 0 or integer number from 1 to 4; q is equal 0 or integer number from 1 to 4; P represents heteroaryl, selected from oxadiazolyl, oxazolyl, triazolyl, benzoimidazolyl, thiazolyl and isoxazolyl, optionally substituted with one or more substituents, selected from group, which consists of atoms of halogen, OH, oxo, SH, NO2, CN, CON(R5)2, NH2, NHCOR5, CO2R5, etc.; W is selected from group, which consists of (C3-C8)cycloalkyl, phenyl, pyrazolyl, cyclohexyl, dihydrobenzofuranyl, benzothiophenyl, pyridinyl, thiazolyl, oxadiazolyl and thiophenyl, optionally substituted with one or more substituents, selected from group, which consists of atoms of halogen, OH, oxo, SH, NH2, NO2, CN, CONHR5, CON(R5)2, NHCOR5, COR5, CO2R5,etc.; R5 represents H or is selected from group, which consists of (C1-C6)alkyl, (C1-C6)halogenalkyl, (C2-C6)alkenyl and (C3-C8)cycloalkyl, op
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充