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Quinuclidine carbonate derivatives and pharmaceutical compositions thereof
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
AMARI, GABRIELE,DELCANALE, MAURIZIO
申请号:
ES09777321
公开号:
ES2384914T3
申请日:
2009.07.21
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of general formula (I) in which: A may be aryl in which one or more hydrogen atoms are optionally substituted with one or more halogen or phenyl or heteroaryl atoms wherein one or more hydrogen atoms are optionally substituted with one or more halogen or arylalkyl or heteroarylalkyl atoms or a group of formula (a) in which R3 and R4 are the same or different and can be independently selected from the group consisting of H, cycloalkyl (C3-C8), aryl or heteroaryl , wherein said aryl or heteroaryl may be optionally substituted with a halogen atom or with one or more substituents independently selected from OH, O-C1-C10 alkyl, oxo (>; = O), SH, S-C1-alkyl -C10), NO2, CN, CONH2, COOH, (C1-C10) alkoxycarbonyl, (C1-C10) alkyl sulfonyl, (C1-C10) alkyl sulfinyl, (C1-C10) alkyl sulfonyl, (C1-C10) alkyl and (C1-C10) alkoxy or when R3 and R4 are both independently aryl or heteroaryl, this s can be linked through a group Y that can be a (CH2) n with n>; = 0-2, where when n>; = 0 Y is a single bond, forming a tricyclic ring system in which the carbon atom of (CH2) n may be substituted with a heteroatom selected from O, S, N and with the proviso that R3 and R4 are never both H. R is a residue selected from: - (C1-C10) alkyl, alkenyl (C2-C10) and alkynyl (C2-C10) optionally substituted with a group selected from: -a group selected from NH2, NR1R2, CONR1R2, NR2COR1, OH, SOR1, SO2R1, SH, CN, NO2 and alicyclic compounds; -Z-R1, in which Z is selected from CO, O, COO, OCO, SO2, S, SO, COS and SCO or is a bond and -cycloalkyl (C3-C8). R1 is a residue selected from: - alicyclic compound optionally substituted with one or more substituents independently selected from OH, oxo (>; = O), SH, NO2, CN, CONH2, NR2CO-(C1-Cx) alkyl, COOH, alkoxy ( C1-C10) carbonyl, (C1-C10) alkyl sulfanyl, (C1-C10) alkyl sulfinyl, (C1-C10) alkyl sulfonyl, (C1-C10) alkyl and (C1-C10) -NR2CO-alkyl (C1-) alkyl C10); - aryl optionally substituted with NR2CO-alkyl (C1-C10) and -heteroaryl optionally
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