MICHAEL PUHL,Klaus DITRICH,Andreas KELLER,Pepa DIMITROVA,Melanie WEINGARTEN,Wolfgang SIEGEL
申请号：
US15510268
公开号：
US20180230176A1
申请日:
2015.09.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a method for preparing 2′-O-fucosyllactose, the 2′-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base.In the formulae (I) and (II), the variables are each defined as follows:RSi are the same or different and are a residue of the formula SiRaRbRc；R1 is a C(═O)—R11 residue or an SiR12R13R14 residue,R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents；R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.
