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Glucokinase ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS AN ACTIVE INGREDIENT
专利权人:
ЭЛ ДЖИ ЛАЙФ САЙЕНСИЗ ЛТД. (KR)
发明人:
КИМ Соон Ха (KR),ЛИ Сунг Бае (KR),ЙООН Сеунг Хиун (KR),ЧО Ми Киоунг (KR),КИМ Киоунг Хее (KR),ПАРК Хеуи Сул (KR),КИМ Хиоунг Дзин (KR)
申请号:
RU2010130095/04
公开号:
RU2010130095A
申请日:
2008.12.22
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Indole derivatives of the following formula (1):! [Formula 1] ! ! wherein ! X represents O or NH,! n denotes a number equal to 0-3,! Y is a direct bond, - (CH2) pO-, - (CH2) q- or - (CH2) qSO2-,! p denotes a number equal to 0-2,! q denotes a number equal to 1-3,! R1 is hydrogen, - (CR4R5) p-A-R6 or - (CR4R5) q-R6,! p and q have the meanings indicated above,! R4 and R5 are independently hydrogen or C1-C5 alkyl,! A is a 6-12 membered aryl or optionally oxo-containing C3-C8 cycloalkyl or is a 3-10 membered heterocyclyl or heteroaryl, each of which has 1-3 heteroatoms selected from O, S and N,! R6 is hydrogen, hydroxy, halogen, nitro, C1-C6 alkylcarbonyl, C1-C6 alkylsulfonyl, C1-C6 alkoxycarbonyl or carboxy,! R2 is hydrogen, nitro, halogen, C1-C6 alkyl or trifluoromethyl, or is 5-12 membered heteroaryl or heterocyclyl, each of which has 1-3 heteroatoms selected from N and O, or is optionally C1-C6 alkylsulfonyl substituted 6-12 membered aryl! R3 is R7-X-B-X'-,! B is a direct bond or is a 3-10 membered heterocyclyl or heteroaryl, each of which optionally contains oxo, is optionally fused and has 1-4 heteroatoms selected from N, O and S,! X and X 'independently of each other represent a direct bond or are selected from the group consisting of -CO-, - (CH2) q-, -NR4C (O) -, -NR4-, -OC (O) -, -O -, - (CH2) pC (O) -, - (CH2) pO-, - (CH2) pNR4-, -C (O) NR4- and -S (O) r-, where p and q have the meanings indicated above, r is a number equal to 0-2, and R4 is hydrogen or C1-C5 alkyl,! R7 is hydrogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, halogen-C1-C6 alkyl or C3-C6 cy1. Производные индола следующей формулы (1): ! [Формула 1] ! ! в которой ! X представляет собой O или NH, ! n обозначает число, равное 0-3, ! Y представляет собой прямую связь, -(CH2)pO-, -(CH2)q- или -(CH2)qSO2-, ! p обозначает число, равное 0-2, ! q обозначает число, равное 1-3, ! R1 представляет собой водород, -(CR4R5)p-A-R6 или -(CR4R5)q-R6, ! p и q имеют значения, указанные выше, ! R4 и R5 неза
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