Compounds useful for treating conditions associated with Dysfunctions in proteostasis, such as Neurodegenerative Diseases, Metabolic, inflammatory and tumor.Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt, solvate, clathrate, or prodrug thereof； where: q u00b9 and q u00b2 are selected independently from each other among the group consisting of nitrogen and cr u2076 u1d43； Sulphur, Oxygen or nr u2075 u1d43； r u00b9 and R u00b2 is SEL Eccionan independently each other between the group consisting of hydrogen,C u2081 u208b u2081 u2080 optionally substituted alkyl, optionally substituted alquenilo c u2082 u208b u2081 u2080, alquinilo c u2082 u208b u2081 u2080 alkoxy optionally substituted cycloalkyl, optionally substituted c u2083 u208b u2081 u2082 c u2081 u208b u2081 u2080, optionally substituted, optionally substituted cicloalquenilo c u2083 u208b u2081 u2082 OJ, optionally substituted heterocycle aryl and heteroaryl substituted, optionally optionally substituted； or, alternatively,R u00b9 and R u00b2 taken together with the nitrogen Atom to which they are United to form an optionally substituted heterocycle or optionally substituted heteroaryl； and is selected from the group consisting of hydrogen and the rest of formula (2)； and (C r u2074 u1d43) (r u2074 u1d47)； and Z is selected Among the group consisting of hydrogen, optionally substituted alkyl c u2081 u208b u2081 u2080,Alquenilo c u2082 u208b u2081 u2080 optionally replaced, alquinilo c u2082 u208b u2081 u2080 optionally replaced, or u00b3, r u00b3, C (o) C (o) C (o) nr u1d43s or u00b3, (OR) u2082r u00b3, OC (o) C (o) r u00b3, nr u1d43r u1d47, S (or S) u2082nr u1d43r u1d47, nr u1d43r u1d47 (OR), (OR) u2082r u00b3, nr u1d43s CN, sr u00b3, S (or S) r u00b3, u2082r u00b3 (o), P (o) (or u00b3 u2082, nr u1d43r u1d47), N (r u1d43 or u00b3 nr u1d43c (), or R u00b3) C (o), (OR) nr u1d43c r u00b3, nr u1d43c nr u1d43r u1d47 nr u1d43s (OR), (OR) u2082nr u1d43r u1d47 c u2083 u208b u2081 u
