YE, Hong;TICE, Colin;SMITHGALL, Thomas;HAIMOWITZ, Thomas;REITZ, Allen;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;FOX CHASE CHEMICAL DEVELOPMENT CENTER, INC.;WROBEL, Jay
发明人:
YE, Hong,SMITHGALL, Thomas,REITZ, Allen,WROBEL, Jay,TICE, Colin,HAIMOWITZ, Thomas,CARLSEN, Marianne,LOUGHRAN, Marie
申请号：
USUS2019/056800
公开号：
WO2020/081856A1
申请日:
2019.10.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A compound of formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof: Formula I wherein X1 is benzimidazolyl, substituted benzimidazolyl, azabenzimidazolyl, substituted azabenzimidazolyl, pyrazolyl, or substituted pyrazolyl； X2 is aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, substituted (cycloalkyl)alkyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, alkyl, substituted alkyl, alkoxycarbonyl, substituted alkoxycarbonyl, dialkylaminocarbonyl, substituted dialkylaminocarbonyl, (heterocycloalkyl)carbonyl, or substituted (heterocycloalkyl)carbonyl； X3 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocycloalkyl, substituted heterocycloalkyl, (heterocycloalkyl)alkyl, substituted (heterocycloalkyl)alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, cycloalkyl, substituted cycloalkyl, (cycloalkyl)alkyl, or substituted (cycloalkyl)alkyl； and X4 is hydroxy, amino, alkyl, or hydrogen.L'invention concerne un composé de formule I, ou un stéréoisomère, un tautomère ou un sel pharmaceutiquement acceptable de celui-ci : formule I, dans laquelle X1 représente un benzimidazolyle, benzimidazolyle substitué, azabenzimidazolyle, azabenzimidazolyle substitué, pyrazolyle, ou pyrazolyle substitué ； X2 représente aryle, aryle substitué, arylalkyle, arylalkyle substitué, hétéroaryle, hétéroaryle substitué, hétéroarylalkyle, hétéroarylalkyle substitué, cycloalkyle, cycloalkyle substitué, (cycloalkyle)alkyle, (cycloalkyle)alkyle substitué, hétérocycloalkyle, hétérocycloalkyle substitué, (hétérocycloalkyle)alkyle, (hétérocycloalkyle)alkyle substitué, alkyle, alkyle substitué, alcoxycarbonyle, alcoxycarbonyle substitué, dialkylaminocarbonyle, dialky
