Pharmaceutical compositions, uses and production processes.Claim 1: a compound having the formula (1) or a pharmaceutically acceptable Salt thereof, wherein a is a compound selected from the group of formulas (2)； X is n, CH or Cr6； x1, X2, X3 and X4 are independently or CR11, X5, X6, X7 and x8 are regardless cr12 Z is n or not； Substituted or replaced by 1 - 2 groups and R7, aryl, Heterocyclic Ring of 5 to 6 members,Or a heteroaryl of 5-6 members； wherein Said Heterocyclic and heteroaryl Ring regardless 1-2 contain heteroatoms selected from N, o and S, R1, R2, R3 and R4 are Hydrogen or alkyl of C1 - 6； R5 and R6 are independently Halo, cyano, alkoxyl C1 - 6 S (or 2r10), or an alkyl Or C1 - 6 unsubstituted or substituted with Halo； Halo R7 is Hydrogen, cyano, alkoxyl alkyl C1 C1 - 6 - 6Alquenilo alquinilo C2 or C2 - 6 - 6, each of which is replaced or not replaced by Halo, amino, hydroxyl, alkoxyl or cyano； nr8r9 W - L -, L -, - C (o) - R10, L - C (o) or10, - L - C (o) nr8r9 or9,； - L - S (o) 2r10 or - L - S (o) 2nr8r9； R8 and R9 are independently Hydrogen or alkyl - L - W, - 6 alquenilo C1, C2 - 6 or Alquinilo C2 - 6, each of which is replaced or not replaced by Halo, amino, hydroxyl,Alkoxyl or cyano； Alternatively, R8 and R9 with the Atoms to which they can form a Ring； alkyl R10 is C1 - 6 or - L - W； R11 and R12 are independently Hydrogen, cyano Halo, alkoxyl, alkyl, or C1 - 6, a C1 - 6 unsubstituted or substituted by Halo； and L IS a link or (CR2) 1 - 4 Where R is H or alkyl of C1 - C3 - 6； W is 7, cycloalkyl, aryl, Heterocyclic Ring of 5 to 6 members,Heteroaryl - 5 or 6 members； wherein Said Heterocyclic and heteroaryl Ring regardless 1-3 contain heteroatoms selected from N, o and S, and N and q are independently 0 - 3.Composiciones farmacéuticas, usos y procesos de obtención.Reivindicación 1: Un compuesto que tiene la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde A es un compuesto seleccionado del grupo de fórmulas (2)； X es N, CH o CR6
