A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: Z is N or CR1, where R1 is selected from H, halo, C1-4 alkyl and C1-4 haloalkyl； R2 and R3 are independently selected from C1-4 alkyl and C1-4haloalkyl, R4 is H or C1-4 alkyl； X is selected from H, halo, C1-4 alkyl, C1-4 haloalkyl, and CN； L is selected from -C≡C-, -CR5>； = CR6-, -O-, -S-, and a direct link between A and the ring containing Z； R5 and R6 are independently selected from H, halo, C1-4 alkyl, and C1-4 haloalkyl； and A is halo, CN, or an optionally substituted group selected from C1-4 alkyl, C3-6 cycloalkyl, phenyl, C2-6 alkenyl, C2-6 alkynyl, 5-6 membered heteroaryl containing up to four heteroatoms selected from N , O and S as ring members, and 4-6 membered heterocyclyl containing up to two heteroatoms selected from N, O and S as ring members, wherein C1-4 alkyl, C3-6 cycloalkyl, phenyl, C2- 6 alkenyl, C2-6alkynyl, 5-6 membered heteroaryl containing up to four heteroatoms selected from N, O and S as ring members, and 4 to 6 membered heterocyclyl containing up to two heteroatoms selected from N, O and S as Ring members are each optionally substituted with up to three groups selected from halo, hydroxy, CN, R10, - (CH2) 0-2OR10, -SR10, -S (O) R10, -SO2R10, -S (O) (NH ) R10, and - (CH2) 0-2N (R10) 2； wherein each R10 is independently H or C1-4 alkyl optionally substituted with one or two groups selected from amino, hydroxy, C1-4 alkoxy, and CN； and -N (R10) 2 may represent a 5-6 membered heterocyclic ring optionally containing an additional heteroatom selected from N, O and S as a ring member, and optionally substituted with one or two groups selected from oxo, halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, and amino.Un compueto de formula (I):**Fórmula** o una sal farmacéuticamente aceptable del mismo, en donde: Z es N o CR1, donde R1 se selecciona de H, halo, C1-4 alquilo y C1-4 haloalquilo； R2 y R3 se seleccionan independientemente de C1-4 alquilo y C1-4haloalqu
