FIELD: biotechnologies.SUBSTANCE: invention relates to substitute nicotine-amide compounds of general formula , where n=0, 1 or 2, p=0 or 1, q=0 or 1, R1 is aryl or heteroaryl or heterocyclyl, non-substitute or mono- or polysubstitute C1-6-alkyl, C3-10-cycloalkyl, non-substitute or mono- or polysubstitute R2 is H or C1-6-alkyl R3 is aryl or pyridyl, non-substitute or mono- or polysubstitute C1-6-alkyl or C3-10-cycloalkyl, in each case non-substitute or mono- or polysubstitute R4, R5, R6 and R7 independently from each other represent H C1-6-alkyl R8, R9 and R10 independently from each other represent H, F, Cl, Br, CF3, C1-6-alkyl where "substitute alkyl", "substitute heterocyclyl" and "substitute cycloalkyl" stands for substitution of hydrogen radical for F, Cl, Br, I, C1-6-alkyl, SH, S-C1-6-alkyl, O-C1-6-alkyl, O-C1-benzyl, -OH, O-C1-6-alkyl-OH, phenyl, phenoxy, morpholynyl or benzyl and "substitute aryl" and "substitute heteroaryl stands for single or multiple substitution of one or several atoms of circular system for F, Cl, Br, I, SH, S-C1-6-alkyl, OH, O-C1-6-alkyl, O-C1-6aryl-OH, CH2SO2-phenyl, OCF3, SCF3, CF3, , , C1-6-alkyl, morpholynyl, phenoxy, phenyl or pyrazolyl provided that if R3 is 3-trifluoromethylphenyl or 4-trifluoromethyl-2-pyridyl, R2, R4 and R5 are H, and n is 0, then R1 is not 2-pyridyl or 2-thienyl and if R3 is or methyl, R2, R4 and R5 are H, and n is 0, then R1 is not 2-thienyl in the form of racemate enantiomers, diastereisomers, mixtures of enantiomers or diastereisomers or a separate enantiomer or diastereisomer bases and/or salts of physiologically acceptable acids. Besides, the invention relates to a pain killer containing specified compounds and to application of the specified compounds for preparation of medicinal agents.EFFECT: new compounds were produced and described, which may find their application in pain treatment.13 cl, 150 ex, 8 tbl, 1 dwgИзобретение относится к замещенным никотинамидным соединениям общей формулы Iгде n=0, 1 или
