WANG, Jianfei (CN),ВАН Цзяньфэй (CN),ZHANG, Yang (CN),ЧЖАН Ян (CN),ZHU, Wenyuan (CN),ЧЖУ Вэньюань (CN),CHEN, Shuhui (CN),ЧЭНЬ Шухуэй (CN)
申请号：
RU2018144818
公开号：
RU0002709473C1
申请日:
2017.05.23
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I),where T is selected from N； R1 is selected from H or C1-6alkyl； each of R2, R3 is independently selected from H, C1-6alkyl or phenyl； or R2 and R3 are interconnected to form C3-6cycloalkyl； R4 is selected from H, F, Cl, Br, I or C1-3alkyl； R5 is selected from H； R6 is selected from H, F, Cl, Br, I or C1-3alkyl； or R5 and R6 are interconnected to form C3-6cycloalkyl or 5-6-member heterocycloalkyl, each of which is optionally substituted with 1, 2 or 3 R； wherein the number of heteroatoms in 5-6-member heterocycloalkyl is selected from 1–3, wherein the heteroatom is O； L is selected from a single bond, -C(=O)NH-； L1 is selected from a single bond, -NH-； R7 is selected from H or selected from a group consisting of C3-6cycloalkyl, phenyl and 5-6-member heteroaryl, each of which is optionally substituted with 1, 2 or 3 R； wherein the number of heteroatoms in 5-6-member heteroaryl is selected from 1–3, wherein the heteroatom is N； R is selected from F, Cl, Br, I, OH, N, N'-di(C1-2 alkyl)amino, C1-3 alkyl-NH-, C1-3 alkyl-O-, C1-3 alkyl-S(=O)2- or C1-6alkyl, which is optionally substituted with 1, 2 or 3 R'； R 'is selected from F, Cl, Br or I； and fragment selected from , used as a uric acid transporter (URAT1) inhibitor, specifically for preparing a pharmaceutical product for treating hyperuricemia and arthritis.EFFECT: proposed are thiophene compound, its production method and its pharmaceutical application.19 cl, 5 tblИзобретение относится к соединению формулы (I),где T выбран из N； R1 выбран из H или C1-6алкила； каждый из R2, R3 независимо выбран из H, C1-6алкила или фенила； или R2 и R3 соединены между собой с образованием C3-6циклоалкила； R4 выбран из H, F, Cl, Br, I или C1-3алкила； R5 выбран из H； R6 выбран из H, F, Cl, Br, I или C1-3алкила； или R5 и R6 соединены между собой с образованием C3-6циклоалкила или 5-6-членного гетероциклоалкила, каждый из которых необязательно замещен 1, 2 или
