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POLYNUCLÉOTIDES CODANT LA RELAXINE
专利权人:
ModernaTX; Inc.
发明人:
XIA, Zhinan,TICHO, Barry,BRIANCON-ERIS, Nadege,DOUSIS, Athanasios,DE PICCIOTTO, Seymour,PRESNYAK, Vladimir,HOGE, Stephen,MCFADYEN, Iain,BENENATO, Kerry,KUMARASINGHE, Ellalahewage, Sathyajith
申请号:
EP17800203
公开号:
EP3458034A4
申请日:
2017.05.18
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The invention relates to mRNA therapy for the treatment of fibrosis and/or cardiovascular disease. mRNAs for use in the invention, when administered in vivo, encode human relaxin, isoforms thereof, functional fragments thereof, and fusion proteins comprising relaxin. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of relaxin expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient relaxin activity in subjects.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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